Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq.

ABSTRACT:

Introduction

Triptolide (TPL) is a promising plant-derived compound for clinical therapy of multiple human diseases; however, its application was limited considering its toxicity.

Methods

To explore the underlying molecular mechanism of TPL nephrotoxicity, a network pharmacology based approach was utilized to predict candidate targets related with TPL toxicity, followed by deep RNA-seq analysis to characterize the features of three transcriptional elements include protein coding genes (PCGs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) as well as their associations with nephrotoxicity in rats with TPL treatment.

Results & discussion

Although the deeper mechanisms of TPL nephrotoxcity remain further exploration, our results suggested that c-Jun is a pote

SUBMITTER: Luo YM 

PROVIDER: S-EPMC10027700 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature