DIA-based technology explores hub pathways and biomarkers of neurological recovery in ischemic stroke after rehabilitation.

ABSTRACT:

Objective

Ischemic stroke (IS) is a common disease that causes severe and long-term neurological disability in people worldwide. Although rehabilitation is indispensable to promote neurological recovery in ischemic stroke, it is limited to providing a timely and efficient reference for developing and adjusting treatment strategies because neurological assessment after stroke treatment is mostly performed using scales and imaging. Therefore, there is an urgent need to find biomarkers that can help us evaluate and optimize the treatment plan.

Methods

We used data-independent acquisition (DIA) technology to screen differentially expressed proteins (DEPs) before and after ischemic stroke rehabilitation treatment, and then performed Gene Ontology (GO) and pathway enrichment analy

SUBMITTER: Hu W 

PROVIDER: S-EPMC10027712 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature