Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state.

ABSTRACT: Biologics, pharmaceuticals containing or derived from living organisms, such as vaccines, antibodies, stem cells, blood, and blood products are a cornerstone of modern medicine. However, nearly all biologics have a major deficiency: they are inherently unstable, requiring storage under constant cold conditions. The so-called 'cold-chain', while effective, represents a serious economic and logistical hurdle for deploying biologics in remote, underdeveloped, or austere settings where access to cold-chain infrastructure ranging from refrigerators and freezers to stable electricity is limited. To address this issue, we explore the possibility of using anhydrobiosis, the ability of organisms such as tardigrades to enter a reversible state of suspended animation brought on by extreme drying, as

SUBMITTER: Packebush MH 

PROVIDER: S-EPMC10027729 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature