Assessment of perfusion deficit with early phases of [¹⁸F]PI-2620 tau-PET versus [¹⁸F]flutemetamol-amyloid-PET recordings.

ABSTRACT:

Purpose

Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can serve for the A/T/N classification of neurodegenerative diseases. Recent studies showed that the early, perfusion-weighted phases of amyloid- or tau-PET recordings serve to detect cerebrometabolic deficits equally to FDG-PET, therefore providing a surrogate of neuronal injury. As such, two channels of diagnostic information can be obtained in the setting of a single PET scan. However, there has hitherto been no comparison of early-phase amyloid- and tau-PET as surrogates for deficits in perfusion/metabolism. Therefore, we undertook to compare [¹⁸F]flutemetamol-amyloid-PET and [¹⁸F]PI-2620 tau-PET as "one-stop shop" dual purpose tracers for the detection of neurodegenerative di

SUBMITTER: Volter F 

PROVIDER: S-EPMC10027797 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature