Biodistribution and dosimetry for combined [¹⁷⁷Lu]Lu-PSMA-I&T/[²²⁵Ac]Ac-PSMA-I&T therapy using multi-isotope quantitative SPECT imaging.

ABSTRACT:

Purpose

Quantitative SPECT for patient-specific dosimetry is a valuable tool in the scope of radionuclide therapy, although its clinical application for ²²⁵Ac-based treatments may be limited due to low therapeutic activities. Therefore, the aim of this study was to demonstrate the feasibility of clinical quantitative low-count SPECT imaging during [¹⁷⁷Lu]Lu-PSMA-I&T/[²²⁵Ac]Ac-PSMA-I&T treatment.

Methods

Eight prostate cancer patients (1000 MBq/8 MBq [¹⁷⁷Lu]Lu-PSMA-I&T/[²²⁵Ac]Ac-PSMA-I&T) received a single-bed quantitative ¹⁷⁷Lu/²²⁵Ac SPECT/CT acquisition (1 h) at 24 h post treatment (high-energy collimator, 16 projections p. head à 3.5 min, 128 × 128 pixel). The gamma peak at 440 keV (width: 10%) of

SUBMITTER: Delker A 

PROVIDER: S-EPMC10027798 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature