[¹⁸F]Fluoride PET provides distinct information on disease activity in ankylosing spondylitis as compared to MRI and conventional radiography.

ABSTRACT:

Purpose

To relate [¹⁸F]fluoride uptake on PET with abnormalities on magnetic resonance imaging (MRI) and conventional radiography (CR) in ankylosing spondylitis (AS) patients.

Methods

Ten clinically active AS patients (female 6/10, age 38 ± 11 years) were included, and both spine and SI-joints were examined. PET scans were dichotomously scored for enhanced [¹⁸F]fluoride uptake, MRI scans were scored for fatty lesions, erosions, ankylosis, and bone marrow edema (BME), and CR was scored for erosions, syndesmophytes, and ankylosis. The overlap of lesions across all modalities was evaluated through univariate and multivariate analyses using a generalized mixed model.

Results

In the spine, 69 lesions with enhanced [¹⁸F]fluoride uptake, 257

SUBMITTER: de Jongh J 

PROVIDER: S-EPMC10027810 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature