Resected Early-Onset Pancreatic Cancer: Practices and Outcomes in an International Dual-Center Study.

ABSTRACT:

Background

Early-onset pancreatic cancer (EOPC), defined as age ≤ 45 years at diagnosis, accounts for 3% of all pancreatic cancer cases. Although differences in tumor biology have been suggested, available data are sparse and specific treatment recommendations are lacking. This study explores the clinicopathological features and oncologic outcomes of resected EOPC.

Patients and methods

Patients with EOPC undergoing resection between 2002 and 2018 were identified from the Heidelberg University Hospital and Johns Hopkins University registries. Median overall survival (OS) and recurrence-free survival (RFS) were analyzed, and prognostic factors were identified.

Results

The final cohort included 164 patients, most of whom had pancreatic ductal adenocarcinoma (PDAC, n = 13

SUBMITTER: Leonhardt CS 

PROVIDER: S-EPMC10027827 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature