Evolutionary conservation of the fidelity of transcription.

ABSTRACT: Accurate transcription is required for the faithful expression of genetic information. However, relatively little is known about the molecular mechanisms that control the fidelity of transcription, or the conservation of these mechanisms across the tree of life. To address these issues, we measured the error rate of transcription in five organisms of increasing complexity and found that the error rate of RNA polymerase II ranges from 2.9 × 10^-6 ± 1.9 × 10^-7/bp in yeast to 4.0 × 10^-6 ± 5.2 × 10^-7/bp in worms, 5.69 × 10^-6 ± 8.2 × 10^-7/bp in flies, 4.9 × 10^-6 ± 3.6 × 10^-7/bp in mouse cells and 4.7 × 10^-6 ± 9.9 × 10^-8/bp in human cells. These error rates were modified by various factor

SUBMITTER: Chung C 

PROVIDER: S-EPMC10027832 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature