Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy.

ABSTRACT: Homeostatic regulation of the maternal milieu during pregnancy is critical for maternal and fetal health. The placenta facilitates critical communication between maternal and fetal compartments, in part, through the production of extracellular vesicles (EVs). EVs enable tissue synchrony via cell-cell and long-distance communication and are at their highest circulating concentration during pregnancy. While much work has been done investigating how physiological challenges in pregnancy affect the fetus, the role of placental communication in maternal health has not been well examined. We previously identified placental O-glycosyl transferase (OGT), a glucose-sensing enzyme, as a target of maternal stress where OGT levels and activity affected the O-glycosylation of proteins critical for EV c

SUBMITTER: Zierden HC 

PROVIDER: S-EPMC10027885 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature