The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study.

ABSTRACT:

Background

Recent studies have shown that ovarian aging is strongly associated with the risk of breast cancer, however, its prognostic impact on breast cancer is not yet fully understood. In this study, we performed a multicohort genetic analysis to explore its prognostic value and biological features in breast cancer.

Methods

The gene expression and clinicopathological data of 3366 patients from the The Cancer Genome Atlas (TCGA) cohort, the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort and the GSE86166 cohort were analyzed. A total of 290 ovarian aging-related genes (OARGs) were included in the establishment of the prognostic model. Furthermore, functional mechanisms analysis, drug sensitivity, and immune cell infiltration were investigated

SUBMITTER: Hua X 

PROVIDER: S-EPMC10027938 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature