Tumor immune microenvironment in therapy-naive esophageal adenocarcinoma could predict the nodal status.

ABSTRACT:

Background

Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and intratumoral and peritumoral immune infiltrating cells could be used to predict loco-regional metastatic disease in early EAC.

Methods

We prospectively evaluated immune markers expression and oncogenes status as well as intratumoral and peritumoral immune infiltrating cells populations in esophageal mucosa samples obtained from neoadjuvant therapy-naïve patients who had esophagectomy for EAC.

Results

Vascular invasion and high infiltration of lamina propria mononuclear cells resulted associated with nodal metastasis. Low infiltrat

SUBMITTER: Kotsafti A 

PROVIDER: S-EPMC10028023 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature