The rational application of liquid biopsy based on next-generation sequencing in advanced non-small cell lung cancer.

ABSTRACT:

Background

Plasma and tissue biopsy have both used for targeting actionable driver gene mutations in lung cancer, whose concordance is imperfect. A reliable method to predict the concordance is urgently needed to ease clinical application.

Methods

A total of 1012 plasma samples, including 519 with paired-tissue biopsy samples, derived from lung adenocarcinoma patients were retrospectively enrolled. We assessed the associations of several clinicopathological characteristics and serum tumor markers with the concordance between plasma and tissue biopsies.

Results

When carcinoembryonic antigen (CEA) levels were higher than thresholds of 15.01 ng/ml and 51.15 ng/ml, the positive predictive value of concordance reached 90% and 95%, respectively. When CEA levels were lower t

SUBMITTER: Zhao C 

PROVIDER: S-EPMC10028052 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature