Genomic alteration profile and PD-L1 expression among different breast cancer subtypes in Chinese population and their correlations.

ABSTRACT:

Backgroud

There were limitations existing in programmed cell-death ligand 1 (PD-L1) as predictive biomarkers for breast cancer (BC), hence exploring the correlation between PD-L1 levels and other biomarkers in BC may become a very useful therapeutic clinical tool.

Methods

A total of 301 Chinese patients with different BC subtypes including 47 HR+/HER2+, 185 HR+/HER2-, 38 HR-/HER2+, and 31 triple-negative breast cancer (TNBC) were enrolled in our study. Next-generation sequencing based Yuansu450 gene panel was used for genomic alteration identification and PD-L1 expression was tested using immunohistochemistry.

Results

The most prevalent BC-related mutations were TP53 mutations, followed by mutations in PIK3CA, ERBB2, CDK12, and GATA3 in our Chinese cohort. We found th

SUBMITTER: Li K 

PROVIDER: S-EPMC10028068 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature