The shared genetic architecture of suicidal behaviour and psychiatric disorders: A genomic structural equation modelling study.

ABSTRACT: Background: Suicidal behaviour (SB) refers to behaviours, ranging from non-fatal suicidal behaviour, such as suicidal ideation and attempt, to completed suicide. Despite recent advancements in genomic technology and statistical methods, it is unclear to what extent the spectrum of suicidal behaviour is explained by shared genetic aetiology. Methods: We identified nine genome-wide association statistics of suicidal behaviour (sample sizes, n, ranging from 62,648 to 125,844), ten psychiatric traits [n up to 386,533] and collectively, nine summary datasets of anthropometric, behavioural and socioeconomic-related traits [n ranging from 58,610 to 941,280]. We calculated the genetic correlation among these traits and modelled this using genomic structural equat

SUBMITTER: Kootbodien T 

PROVIDER: S-EPMC10028147 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature