A pyroptosis-related lncRNA signature in bladder cancer.

ABSTRACT:

Purpose

Pyroptosis, a type of programmed cell death, is implicated in the tumorigenesis, development and migration of cancer, which can be regulated by long non-coding RNAs (lncRNAs). Our research aimed to investigate the prognostic role of pyroptosis-related lncRNAs and the relationship to the tumor immune microenvironment through bioinformatics analysis.

Methods

The clinical and RNA-sequencing data of bladder cancer patients were downloaded from The Cancer Genome Atlas (TCGA). And 412 bladder cancer subjects with clinical information were divided into training and testing cohort. And 52 reported pyroptosis-related genes were used to screen pyroptosis-related lncRNAs. A pyroptosis-related lncRNA signature was constructed based on Cox regression analyses.

Results

A 9-

SUBMITTER: Wang P 

PROVIDER: S-EPMC10028168 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature