Costimulatory molecule-related lncRNA model as a potential prognostic biomarker in non-small cell lung cancer.

ABSTRACT:

Objective

Costimulatory molecules have been demonstrated to exert essential roles in multiple cancers. However, their role in lung cancer remains elusive. Here, we sought to identify costimulatory molecule-related lncRNAs in non-small cell lung cancer (NSCLC) and establish a prognostic signature to predict the prognosis of patients with NSCLC.

Methods

A total of 535 lung adenocarcinoma (LUAD) and 502 lung squamous cell carcinoma (LUSC) patients from the cancer genome atlas (TCGA) database were recruited. A novel costimulatory molecule-based lncRNA prognostic model was constructed using the least absolute shrinkage and selection operator (LASSO) algorithm to predict the overall survival. The Homo_sapiens.GRCh38 data set was set as a reference file for probe annotation.

Res

SUBMITTER: Yao Y 

PROVIDER: S-EPMC10028169 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature