Assessment of adaptive immune responses of dairy cows with Burkholderia contaminans-induced mastitis.

ABSTRACT: Burkholderia contaminans, an emerging pathogen related to cystic fibrosis, is known to cause potentially fatal infections in humans and ruminants, especially in immunocompromised individuals. However, the immune responses in cows following its infection have not been fully elucidated. In this study, T- and B-lymphocytes-mediated immune responses were evaluated in 15 B. contaminans-induced mastitis cows and 15 healthy cows with multi-parameter flow cytometry. The results showed that infection with B. contaminans was associated with a significant decrease in the number and percentage of B lymphocytes but with a significant increase in the proportion of IgG⁺CD27⁺ B lymphocytes. This indicated that humoral immune response may not be adequate to fight

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10028201 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature