Solid-state ion-selective electrodes for the first potentiometric determination of the anti-COVID 19 drug Remdesivir in human plasma; A comparative study.

ABSTRACT: Establishing sensitive and targeted analytical methodologies for drug identification in biological fluids as well as screening of treatments that can counteract the most severe COVID-19 infection-related side effects are of utmost importance. Here, first attempts have been made for determination of the anti-COVID drug Remdesivir (RDS) in human plasma using four potentiometric sensors. Calixarene-8 (CX8) was used as an ionophore applied to the first electrode (Sensor I). The second had a layer of dispersed graphene nanocomposite coating (Sensor II). (Sensor III) was fabricated using nanoparticles of polyaniline (PANI) as ion-to-electron transducer. A reverse-phase polymerization using polyvinylpyrrolidone (PVP) was employed to create a graphene-polyaniline (G/PANI) nanocomposite electrode (

SUBMITTER: El Azab NF 

PROVIDER: S-EPMC10028218 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature