Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea.

ABSTRACT:

Importance

Metformin may have a protective association against developing osteoarthritis (OA), but robust epidemiological data are lacking.

Objective

To determine the risk of OA and joint replacement in individuals with type 2 diabetes treated with metformin compared with a sulfonylurea.

Design, setting, and participants

This retrospective cohort study used claims data from the Optum deidentified Clinformatics Data Mart Database between December 2003 and December 2019. Participants included individuals aged 40 years or older with at least 1 year of continuous enrollment and type 2 diabetes. Individuals with type 1 diabetes or a prior diagnosis of OA, inflammatory arthritis, or joint replacement were excluded. Time-conditional propensity score matching was conducted us

SUBMITTER: Baker MC 

PROVIDER: S-EPMC10028483 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature