Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule.

ABSTRACT: Through its classic ATP-dependent ion-pumping function, basolateral Na/K-ATPase (NKA) generates the Na⁺ gradient that drives apical Na⁺ reabsorption in the renal proximal tubule (RPT), primarily through the Na⁺ /H⁺ exchanger (NHE3). Accordingly, activation of NKA-mediated ion transport decreases natriuresis through activation of basolateral (NKA) and apical (NHE3) Na⁺ reabsorption. In contrast, activation of the more recently discovered NKA signaling function triggers cellular redistribution of RPT NKA and NHE3 and decreases Na⁺ reabsorption. We used gene targeting to test the respective contributions of NKA signaling and ion pumping to the overall regulation of RPT Na⁺ reabsorption. Knockdown of RPT NKA in cells

SUBMITTER: Mukherji ST 

PROVIDER: S-EPMC10028530 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature