Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the frontoparietal networks.

ABSTRACT: Anaesthesia combined with functional neuroimaging provides a powerful approach for understanding the brain mechanisms of consciousness. Although propofol is used ubiquitously in clinical interventions that reversibly suppress consciousness, it shows large inter-individual variability, and the brain bases of this variability remain poorly understood. We asked whether three networks key to conscious cognition-the dorsal attention (DAN), executive control (ECN), and default mode (DMN)-underlie responsiveness variability under anaesthesia. Healthy participants (N = 17) were moderately anaesthetized during narrative understanding and resting-state conditions inside the Magnetic Resonance Imaging scanner. A target detection task measured behavioural responsiveness. An independent behavioural stu

SUBMITTER: Deng F 

PROVIDER: S-EPMC10028637 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature