Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task.

ABSTRACT: Childhood maltreatment (CM) and a family history (FH) of alcohol use disorder (AUD) are each associated with increased impulsivity. However, their unique or shared brain targets remain unknown. Furthermore, both CM and FH demonstrate sex-dependent effects on brain and behavior. We hypothesized that CM and FH interact in brain regions involved in impulsivity with sex-dependent effects. 144 first-year college students (18-19 years old) with varying experiences of CM and/or FH but without current AUD performed an fMRI stop-signal task. We tested interactions between FH, CM, and sex on task performance and blood oxygen level-dependent (BOLD) signal during successful inhibitions. We examined correlations between BOLD response and psychiatric symptoms. Significant three-way interactions of FH, C

SUBMITTER: Elton A 

PROVIDER: S-EPMC10028663 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature