Whole-brain functional gradients reveal cortical and subcortical alterations in patients with episodic migraine.

ABSTRACT: Migraine is a type of headache with multiple neurological symptoms. Prior neuroimaging studies in patients with migraine based on functional magnetic resonance imaging have found regional as well as network-level alterations in brain function. Here, we expand on prior studies by establishing whole-brain functional connectivity patterns in patients with migraine using dimensionality reduction techniques. We studied functional brain connectivity in 50 patients with episodic migraine and sex- and age-matched healthy controls. Using dimensionality reduction techniques that project high-dimensional functional connectivity onto low-dimensional representations (i.e., eigenvectors), we found significant between-group differences in the eigenvectors between patients with migraine and healthy contro

SUBMITTER: Lee CH 

PROVIDER: S-EPMC10028679 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature