Intradermal needle-free injection prevents African Swine Fever transmission, while intramuscular needle injection does not.

ABSTRACT: Shared needles are a possible iatrogenic and hematogenous inanimate vector of African Swine Fever virus (ASFV) in farm conditions. To evaluate that possible transmission, sixty, 4-week-old pigs were procured from an ASF free herd free. Upon arrival, pigs were randomly divided into two sets. Set 1 served as seeder pigs, and were randomly allocated to 4 groups. The other pigs were divided into 8 groups, and served as sentinels. Seeder pigs were oronasally challenged with ASFV at high (10⁸ copy numbers/mL), moderate (10⁶ copy numbers/mL) or low (10¹ copy numbers/mL) challenge titer, except a subgroup that remained unchallenged (negative control). At 7 days post challenge (peak viremia), all four seeder groups were intradermally and intramuscularly (IM) injecte

SUBMITTER: Salman M 

PROVIDER: S-EPMC10028754 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature