Human memory T cell dynamics after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccination.

ABSTRACT: This study evaluates the functional capacity of CD4⁺ and CD8⁺ terminally-differentiated effector (T_EMRA), central memory (T_CM), and effector memory (T_EM) cells obtained from the volunteers vaccinated with an aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac). The volunteers were followed for T cell immune responses following the termination of a randomized phase III clinical trial. Seven days and four months after the second dose of the vaccine, the memory T cell subsets were collected and stimulated by autologous monocyte-derived dendritic cells (mDCs) loaded with SARS-CoV-2 spike glycoprotein S1. Compared to the placebo group, memory T cells from the vaccinated individuals significantly proliferated in respon

SUBMITTER: Tavukcuoglu E 

PROVIDER: S-EPMC10028771 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature