Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.

ABSTRACT: The neural crest (NC) is highly multipotent and generates diverse lineages in the developing embryo. However, spatiotemporally distinct NC populations display differences in fate potential, such as increased gliogenic and parasympathetic potential from later migrating, nerve-associated Schwann cell precursors (SCPs). Interestingly, while melanogenic potential is shared by both early migrating NC and SCPs, differences in melanocyte identity resulting from differentiation through these temporally distinct progenitors have not been determined. Here, we leverage a human pluripotent stem cell (hPSC) model of NC temporal patterning to comprehensively characterize human NC heterogeneity, fate bias, and lineage development. We captured the transition of NC differentiation between temporally and tr

SUBMITTER: Samuel RM 

PROVIDER: S-EPMC10028814 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature