A molecularly defined and spatially resolved cell atlas of the whole mouse brain.

ABSTRACT: In mammalian brains, tens of millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate organization of cells in the brain have so far hindered our understanding of the molecular and cellular basis of its functions. Recent advances in spatially resolved single-cell transcriptomics have allowed systematic mapping of the spatial organization of molecularly defined cell types in complex tissues^1-3. However, these approaches have only been applied to a few brain regions^1-11 and a comprehensive cell atlas of the whole brain is still missing. Here, we imaged a panel of >1,100 genes in ~8 million cells across the entire adult mouse brain using multiplexed error-robust fluorescence in situ hybridiz

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10028822 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature