Hadza Prevotella Require Diet-derived Microbiota Accessible Carbohydrates to Persist in Mice.

ABSTRACT: Industrialization has transformed the gut microbiota, reducing the prevalence of Prevotella relative to Bacteroides. Here, we isolate Bacteroides and Prevotella strains from the microbiota of Hadza hunter-gatherers of Tanzania, a population with high levels of Prevotella. We demonstrate that plant-derived microbiota-accessible carbohydrates (MACs) are required for persistence of Prevotella copri but not Bacteroides thetaiotaomicron in vivo. Differences in carbohydrate metabolism gene content, expression, and in vitro growth reveal that Hadza Prevotella strains specialize in degrading plant carbohydrates, while Hadza Bacteroides isolates use both plant and host-derived carbohydrates, a difference mirrored in Bacteroide

SUBMITTER: Gellman RH 

PROVIDER: S-EPMC10028851 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature