Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior.

ABSTRACT:

Introduction

Hippocampal sclerosis of aging (HS) is an important component of combined dementia neuropathology. However, the temporal evolution of its histologically-defined features is unknown. We investigated pre-mortem longitudinal hippocampal atrophy associated with HS, as well as with other dementia-associated pathologies.

Methods

We analyzed hippocampal volumes from MRI segmentations in 64 dementia patients with longitudinal MRI follow-up and post-mortem neuropathological evaluation, including HS assessment in the hippocampal head and body.

Results

Significant HS-associated hippocampal volume changes were observed thoughout the evaluated timespan, up to 11.75 years before death. These changes were independent of age and Alzheimer’s Disease (AD) burden, and spe

SUBMITTER: Ortega-Cruz D 

PROVIDER: S-EPMC10028863 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature