The ComRS-SigX pathway regulates natural transformation in Streptococcus ferus.

ABSTRACT: The ability to take up and incorporate foreign DNA via natural transformation is a well-known characteristic of some species of Streptococcus, and is a mechanism that rapidly allows for the acquisition of antibacterial resistance. Here, we describe that the understudied species Streptococcus ferus is also capable of natural transformation and uses a system analogous to that identified in Streptococcus mutans . S. mutans natural transformation is under the control of the alternative sigma factor sigX (also known as comX ), whose expression is induced by two types of peptide signals: CSP ( c ompetence s timulating p eptide, encoded by comC ) and XIP ( sig X -inducing p eptide, encoded by comS ). These systems induce competence vi

SUBMITTER: Rued BE 

PROVIDER: S-EPMC10028898 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature