Exploring the evolution and function of Canoea€™s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis.

ABSTRACT: One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway. We focus on Drosophila Canoe, homolog of mammalian Afadin, as a model for defining the underlying mechanisms. Canoe and Afadin are complex, multidomain proteins that share multiple domains with defined and undefined binding partners. Both also share a long carboxy-terminal intrinsically disordered reg

SUBMITTER: Gurley NJ 

PROVIDER: S-EPMC10028902 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature