Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition.

ABSTRACT: The human cerebral cortex exhibits intricate interareal functional synchronization at the macroscale, with substantial individual variability in these functional connections. However, the spatial organization of functional connectivity (FC) variability across the human connectome edges and its significance in cognitive development remain unclear. Here, we identified a connectional axis in the edge-level FC variability. The variability declined continuously along this axis from within-network to between-network connections, and from the edges linking association networks to those linking the sensorimotor and association networks. This connectional axis of functional variability is associated with spatial pattern of structural connectivity variability. Moreover, the connectional variability

SUBMITTER: Yang H 

PROVIDER: S-EPMC10028904 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature