Ontology highlight
ABSTRACT:
SUBMITTER: Boeynaems S
PROVIDER: S-EPMC10028949 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Boeynaems Steven S Ma X Rosa XR Yeong Vivian V Ginell Garrett M GM Chen Jian-Hua JH Blum Jacob A JA Nakayama Lisa L Sanyal Anushka A Briner Adam A Haver Delphi Van DV Pauwels Jarne J Ekman Axel A Schmidt H Broder HB Sundararajan Kousik K Porta Lucas L Lasker Keren K Larabell Carolyn C Hayashi Mirian A F MAF Kundaje Anshul A Impens Francis F Obermeyer Allie A Holehouse Alex S AS Gitler Aaron D AD
bioRxiv : the preprint server for biology 20230309
Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-spectrometry-based proteomics to define the protein targets of these neurotoxic peptides and found that they all share similar sequence features that drive their aberrant condensation with these positively charged peptides. We trained a machine learnin ...[more]