Structural basis for differential p19 targeting by IL-23 biologics.

ABSTRACT:

Background

IL-23 is central to the pathogenesis of psoriasis, and is structurally comprised of p19 and p40 subunits. "Targeted" IL-23 inhibitors risankizumab, tildrakizumab, and guselkumab differ mechanistically from ustekinumab because they bind p19, whereas ustekinumab binds p40; however, a knowledge gap exists regarding the structural composition of their epitopes and how these molecular properties relate to their clinical efficacy.

Objectives

To characterize and differentiate the structural epitopes of the IL-23 inhibitors risankizumab, guselkumab, tildrakinumab, and ustekinumab, and correlate their molecular characteristics with clinical response in plaque psoriasis therapy.

Methods

We utilized epitope data derived from hydrogen-deuterium exchange studies for ris

SUBMITTER: Daniele SG 

PROVIDER: S-EPMC10029002 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature