Dataset Information

Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

ABSTRACT: Frontal circuits play a critical role in motor, cognitive, and affective processing - and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)function remains largely elusive. Here, we study 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregate the frontal cortex into circuits that became dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to rostral, ranging from interconnections with sensorimotor cortices in dystonia, with the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairment in the human brain.

SUBMITTER: Hollunder B

PROVIDER: S-EPMC10029043 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

Hollunder Barbara B Ostrem Jill L JL Sahin Ilkem Aysu IA Rajamani Nanditha N Oxenford Simón S Butenko Konstantin K Neudorfer Clemens C Reinhardt Pablo P Zvarova Patricia P Polosan Mircea M Akram Harith H Vissani Matteo M Zhang Chencheng C Sun Bomin B Navratil Pavel P Reich Martin M MM Volkmann Jens J Yeh Fang-Cheng FC Baldermann Juan Carlos JC Dembek Till A TA Visser-Vandewalle Veerle V Alho Eduardo Joaquim Lopes EJL Franceschini Paulo Roberto PR Nanda Pranav P Finke Carsten C Kühn Andrea A AA Dougherty Darin D DD Richardson R Mark RM Bergman Hagai H DeLong Mahlon R MR Mazzoni Alberto A Romito Luigi M LM Tyagi Himanshu H Zrinzo Ludvic L Joyce Eileen M EM Chabardes Stephan S Starr Philip A PA Li Ningfei N Horn Andreas A

medRxiv : the preprint server for health sciences 20230825

Frontal circuits play a critical role in motor, cognitive, and affective processing - and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)function remains largely elusive. Here, we study 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregate the frontal cortex into circuits tha ...[more]

PMID: 36945497

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Project description:The medial frontal cortex remains functionally ill-understood; this is reflected by the heterogeneity of behavioural outcomes following damage to the region. We aim to use the rich information provided by extraoperative direct electrical cortical stimulation to enhance our understanding of its functional anatomy. Examining a cohort of 38 epilepsy patients undergoing direct electrical cortical stimulation in the context of presurgical evaluation, we reviewed stimulation findings and classified them in a behavioural framework (positive motor, negative motor, somatosensory, speech disturbances, and "other"). The spatially discrete cortical stimulation-derived data points were then transformed into continuous probabilistic maps, thereby enabling the voxel-wise spatial inference widely used in the analysis of functional and structural imaging data. A functional map of stimulation findings of the medial wall emerged. Positive motor responses occurred in 141 stimulations (31.2%), anatomically located on the paracentral lobule (threshold at p<.05), extending no further than the vertical anterior commissure (VCA) line. Thirty negative motor responses were observed (6.6%), localised to the VCA line (at p < .001 uncorrected). In 43 stimulations (9.5%) a somatosensory response localised to the caudal cingulate zone (at p < .001 uncorrected), with a second region posterior to central sulcus. Speech disturbances were elicited in 38 stimulations (8.4%), more commonly but not exclusively from the language fMRI dominant side, just anterior to VCA (p < .001 uncorrected). In only 2 stimulations, the patient experienced a subjective "urge" to move in the absence of overt movement. Classifying motor behaviour along the dimensions of effector, and movement vs arrest, we derive a wholly data-driven stimulation map of the medial wall, powered by the largest number of stimulations of the region reported (n = 452) in patients imaged with MRI. This model and the underlying data provide a robust framework for understanding the architecture of the region through the joint analysis of disruptive and correlative anatomical maps.

Dataset Information

Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

Publications

Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

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