Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

ABSTRACT: Frontal circuits play a critical role in motor, cognitive, and affective processing - and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)function remains largely elusive. Here, we study 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregate the frontal cortex into circuits that became dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to rostral, ranging from interconnections with sensorimotor cortices in dystonia, with the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to

SUBMITTER: Hollunder B 

PROVIDER: S-EPMC10029043 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature