Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.

ABSTRACT: Increasing evidence supports the role of placenta in neurodevelopment and potentially, in the later onset of neuropsychiatric disorders. Recently, methylation quantitative trait loci (mQTL) and interaction QTL (iQTL) maps have proven useful to understand SNP-genome wide association study (GWAS) relationships, otherwise missed by conventional expression QTLs. In this context, we propose that part of the genetic predisposition to complex neuropsychiatric disorders acts through placental DNA methylation (DNAm). We constructed the first public placental cis-mQTL database including nearly eight million mQTLs calculated in 368 fetal placenta DNA samples from the INMA project, ran cell type- and gestational age-imQTL models and combined those data with the summary statistics of the largest

SUBMITTER: Cilleros-Portet A 

PROVIDER: S-EPMC10029044 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature