Evaluating targeted COVID-19 vaccination strategies with agent-based modeling.

ABSTRACT: We evaluate approaches to vaccine distribution using an agent-based model of human activity and COVID-19 transmission calibrated to detailed trends in cases, hospitalizations, deaths, seroprevalence, and vaccine breakthrough infections in Florida, USA. We compare the incremental effectiveness for four different distribution strategies at four different levels of vaccine availability, reflecting different income settings' historical COVID-19 vaccine distribution. Our analysis indicates that the best strategy to reduce severe outcomes is to actively target high disease-risk individuals. This was true in every scenario, although the advantage was greatest for the middle-income-country availability assumptions, and relatively modest compared to a simple mass vaccination approach for rapid, hig

SUBMITTER: Hladish TJ 

PROVIDER: S-EPMC10029084 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature