Establishing a prognostic model of chromatin modulators and identifying potential drug candidates in renal clear cell patients.

ABSTRACT:

Background

Renal carcinoma is a common malignant tumor of the urinary system. Advanced renal carcinoma has a low 5-year survival rate and a poor prognosis. More and more studies have confirmed that chromatin regulators (CRs) can regulate the occurrence and development of cancer. This article investigates the functional and prognostic value of CRs in renal carcinoma patients.

Methods

mRNA expression and clinical information were obtained from The Cancer Genome Atlas database. Univariate Cox regression analysis and LASSO regression analysis were used to select prognostic chromatin-regulated genes and use them to construct a risk model for predicting the prognosis of renal cancer. Differences in prognosis between high-risk and low-risk groups were compared using Kaplan-Meier an

SUBMITTER: Liu P 

PROVIDER: S-EPMC10029171 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature