TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration.

ABSTRACT:

Background

The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box family of transcription factors previously shown to regulate pluripotency and subsequent lineage commitment in a number of tissues, including limb and lung. TBX3 is also involved in lung and heart organogenesis. Here, we provide a comprehensive and thorough characterization of TBX3 and its role during pancreatic organogenesis and regeneration.

Results

We interrogated the level and cell specificity of TBX3 in the developing and adult pancreas at mRNA and protein levels at multiple developmental stages in mouse and human pancreas. We employed conditional mutagenesis to determine its role in murine pancreatic

SUBMITTER: Melzer MK 

PROVIDER: S-EPMC10029195 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature