Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish.

ABSTRACT:

Background

Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-descent (IBD) haplotypes are inherited from each parent. Population isolates with a small set of common founders have elevated autozygosity relative to outbred populations.

Methods

In this study, we examined whether degree of autozygosity was associated with variation in 96 cardiometabolic traits among 7221 Old Order Amish individuals residing in Lancaster County, PA. We estimated the average length of an ROH segment to be 6350 KB, with each individual having on average 17.2 segments 1.5 KB

SUBMITTER: Lynch MT 

PROVIDER: S-EPMC10029202 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature