Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification.

ABSTRACT:

Background

Osteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroyed bone microarchitecture. Previous studies found that Lycium Chinense Mill (LC) has a potent role in inhibiting bone loss. Kukoamine A (KuA), a bioactive compound extract from LC was responsible for the anti-osteoporosis effect. This study aimed to investigate the anti-osteoporosis effect of KuA isolated from LC in treating OP and its potential molecular mechanism.

Method

In this study, network pharmacology and molecular docking were investigated firstly to find the active ingredients of LC such as KuA, and the target genes of OP by the TCMSP platform. The LC-OP-potential Target gene network was constructed by the STRING database and network m

SUBMITTER: Luo L 

PROVIDER: S-EPMC10029210 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature