Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol.

ABSTRACT:

Background

The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational studies suffer from the effect of confounding factors. The controlled experimental environment afforded by preclinical studies allows for clarification and mechanistic evaluation of sex-dependent differences. We propose a systematic review to assess the impact of biological sex on baseline responses to disease induction as well as treatment responses in animal models of sepsis. Given the lack of guidance surrounding sex-based analyses in preclinical systematic reviews, careful consideration of various factors is needed to understand how best to co

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10029211 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature