Zika virus RNA and IgM persistence in blood compartments and body fluids: a prospective observational study.

ABSTRACT:

Background

Characterisation of the dynamics of Zika virus persistence following acute infection is needed to inform blood donor and diagnostic testing policies and understand the natural history of Zika virus infection. We aimed to characterise the natural history, persistence, and clinical outcomes of Zika virus infection through a prospective study in initially asymptomatic Zika virus RNA-positive blood donors.

Methods

Zika virus-infected blood donors identified through Zika virus nucleic acid amplification test (NAAT) screening at three blood collection organisations in the USA were enrolled into a 1-year follow-up study, with blood and body fluid samples and detailed symptom data collected at up to seven visits. All samples were tested for Zika virus RNA by real-time PCR

SUBMITTER: Stone M 

PROVIDER: S-EPMC10029720 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature