A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip.

ABSTRACT: Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) and fibrosis. The limited number of FDA-approved inhaled drugs for these serious lung conditions has led to a shift from in vivo towards the use of alternative in vitro human-relevant models to better predict the toxicity of inhaled particles in preclinical research. While there are several inhalation exposure models for the upper airways, the fragile and dynamic nature of the alveolar microenvironment has limited the development of reproducible exposure models for the distal lung. Here, we present a mechanistic approach using a new generation of exposure systems, the Cloud α AX12. This n

SUBMITTER: Sengupta A 

PROVIDER: S-EPMC10029733 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature