Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19.

ABSTRACT:

Purpose

Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19.

Methods

We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, and whole blood gene expression profiles in convalescent severe COVID-19 patients 1, 3, and 6 months following hospital discharge.

Results

We observed persistent abnormalities until month 6 marked by (i) high serum levels of monocyte/macrophage and endothelial activation markers, chemotaxis, and hematopoietic cytokines; (ii) a high frequency of central memory CD4⁺ and effector CD8⁺ T cells; (iii) a decrease in

SUBMITTER: Hocini H 

PROVIDER: S-EPMC10029801 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature