Interaction between secondary mitral regurgitation and left atrial function and their prognostic implications after cardiac resynchronization therapy.

ABSTRACT:

Aims

Left atrial (LA) function is a strong prognostic marker in patients with heart failure and functional mitral regurgitation (MR). Although cardiac resynchronization therapy (CRT) has shown to improve MR severity, the interaction between a reduction in MR severity and an increase in LA function, as well as its association with outcomes, has not been investigated.

Methods and results

LA reservoir strain (RS) was evaluated with speckle tracking echocardiography in patients with at least moderate functional MR undergoing CRT implantation. MR improvement was defined as at least 1 grade improvement in MR severity at 6 months after CRT implantation. The primary endpoint was all-cause mortality. A total of 340 patients (mean age 66 ± 10 years, 73% male) were included, of whom 20

SUBMITTER: Stassen J 

PROVIDER: S-EPMC10029846 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature