Early Differentiation of Irreversible Electroporation Ablation Regions With Radiomics Features of Conventional MRI.

ABSTRACT:

Rationale and objectives

Irreversible electroporation (IRE) is a promising non-thermal ablation technique for the treatment of patients with hepatocellular carcinoma. Early differentiation of the IRE zone from surrounding reversibly electroporated (RE) penumbra is vital for the evaluation of treatment response. In this study, an advanced statistical learning framework was developed by evaluating standard MRI data to differentiate IRE ablation zones, and to correlate with histological tumor biomarkers.

Materials and methods

Fourteen rabbits with VX2 liver tumors were scanned following IRE ablation and forty-six features were extracted from T1w and T2w MRI. Following identification of key imaging variables through two-step feature analysis, multivariable classification and reg

SUBMITTER: Eresen A 

PROVIDER: S-EPMC10029937 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature