Predictive factors of distant metastasis in surgically treated HPV-positive tonsil cancer.

ABSTRACT:

Background

Human papilloma virus (HPV)-related tonsil cancer is associated with favorable outcomes.

Objective

The purpose of this study was to define factors affecting distant metastasis in patients with surgically treated HPV-positive tonsil cancer.

Methods

The present study enrolled 76 patients diagnosed with HPV-positive tonsil cancer who underwent primary surgery between January 2010 and December 2021.

Results

Twelve (15.7%) patients experienced a distant failure with a median follow-up time of 43 months. Sites of distant metastasis included the lung (n = 10), liver (n = 1), and brain (n = 1). Upon multivariate analysis, an advanced T stage (odds ratio [OR]: 13.94, 95% confidence interval [CI]: 1.29-149.863, p = 0.003) and margin involvement (OR: 5.96, 95%

SUBMITTER: Shin HI 

PROVIDER: S-EPMC10030005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature