Recurrent network interactions explain tectal response variability and experience-dependent behavior.

ABSTRACT: Response variability is an essential and universal feature of sensory processing and behavior. It arises from fluctuations in the internal state of the brain, which modulate how sensory information is represented and transformed to guide behavioral actions. In part, brain state is shaped by recent network activity, fed back through recurrent connections to modulate neuronal excitability. However, the degree to which these interactions influence response variability and the spatial and temporal scales across which they operate, are poorly understood. Here, we combined population recordings and modeling to gain insights into how neuronal activity modulates network state and thereby impacts visually evoked activity and behavior. First, we performed cellular-resolution calcium imaging of the o

SUBMITTER: Zylbertal A 

PROVIDER: S-EPMC10030118 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature