Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in rats.

ABSTRACT:

Objective

The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage.

Methods

Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg/kg/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg/kg cyclophosphamide and 100 mg/kg/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus.

Results

SUBMITTER: Bulbul M 

PROVIDER: S-EPMC10030208 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature